7/10/2023 0 Comments Activator proteinUpon T-cell activation, genes involved in cholesterol biosynthesis are upregulated while genes that promote cholesterol efflux are repressed. HDAC3-deficient CD4 + T cells failed to proliferate and blast after in vitro TCR/CD28 stimulation. ![]() Here, we show that histone deacetylase 3 (HDAC3) is critical for activation of murine peripheral CD4 + T cells. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols. ![]() After antigenic activation, quiescent naive CD4 + T cells alter their metabolism to proliferate.
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